Cholesterol crystals, smooth muscle cells and new data on the genesis of atherosclerosis.

JH Kiyak - Polish Journal of Pathology: Official Journal of the …, 1997 - europepmc.org
The histologic appearance of atherosclerosis has been well described but its pathogenesis
is still vigorously debated. The purpose of the present study is to clarify the stimuli for smooth
muscle cells (SMC) migration and proliferation as well as the way of cholesterol crystals
(CC) generation. We performed postmortem ultrastructural analysis of myocardial samples
obtained from 45 patients (33 males, 12 females, age range 18-85) who died from different
diseases, mainly from acute myocardial infarction-MI (37 cases). Tissue was taken by …
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